When the Dearly's Dalmatians have their first litter of puppies - fifteen in all - everyone is delighted. But their joy is shattered when the pups are kidnapped! The humans don't have a clue as to who the culprit is, but the smartest dogs in London are on the case - and on the trail of the fur-loving Cruella de Vil, who will stop at nothing to have a Dalmatian fur coat!