When Erasmus Crane, the famous occult detective is called to investigate the murder and mutilation of a young woman he is instantly both repulsed and terrified. Not only by the gruesome nature of the killing and the strange squid like formations the murderer has made of the entrails but also by what those strange symbols mean. Erasmus, has seen them before.

The Cthulhu Murders drag Erasmus and his faithful companion into a dark and secretive world of esoteric books, ritual sacrifice and deals with dangerous entities far beyond human understanding. Entities that once invoked, threaten to wake up, hungry.