Mark Robarts, a young vicar, is newly arrived in the village of Framley. With ambitions to further his career, he seeks connections in the county's high society. He is soon preyed upon by a local member of parliament to guarantee a substantial loan, which Mark in a moment of weakness agrees to—despite knowing the man is a notorious debtor—and which brings him to the brink of ruin. He must face the awful reality this loss will bring his family.

Meanwhile, Mark's sister, Lucy, is deeply in love with Lord Lufton, the son of the lofty Lady Lufton. Lord Lufton has proposed, but Lady Lufton is against the marriage, preferring that her son choose the coldly beautiful Griselda Grantly.

The novel will conclude with four happy marriages, including one involving Doctor Thorne, the hero of the preceding book in the Chronicles of Barsetshire series.

One of Trollope's most popular novels, Framley Parsonage depicts nineteenth-century country life beautifully, crafted with acute insight into human nature.