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Inside the O'Briens: A Novel

Unabridged Audiobook

Written By: Lisa Genova

Narrated By: Skipp Sudduth

Publisher: Simon & Schuster

Date: April 2015

Duration: 11 hours 14 minutes


From award-winning, New York Times bestselling author Lisa Genova comes a powerful new novel that does for Huntington’s Disease what her debut Still Alice did for Alzheimer’s.

Joe O’Brien is a forty-four-year-old Boston police officer from the Irish Catholic neighborhood of Charlestown, Massachusetts. A devoted husband, a proud father of four children in their twenties, and a respected, seasoned law enforcement officer, Joe begins experiencing bouts of disorganized thinking, uncharacteristic temper outbursts, and strange, involuntary movements. He initially attributes these episodes to aging and the cumulative physical and psychological stress of his job, but as these symptoms worsen, he agrees to see a neurologist and is handed a diagnosis that will change his and his family’s lives forever: Huntington’s Disease.

Huntington’s is a lethal neurodegenerative disease with no treatment that affects the progression and no cure. And it is genetic. Each of Joe’s four children has a 50 percent chance of inheriting their father’s disease, and a simple blood test can reveal their genetic fate. While watching their potential future in their father’s escalating symptoms, each child struggles with the questions this test imposes on their young adult lives, including his youngest, twenty-one-year-old Katie. Does she want to know? What if she’s gene positive? Can she live with the constant anxiety of not knowing?

As Joe’s symptoms worsen and he’s eventually stripped of his badge and more, he struggles to maintain his identity and sense of purpose. How can he find hope in a situation that feels hopeless? How can he find courage without any armor or weapons? What else might he be able to pass down to his children other than a fatal disease? Where is the honor in living and dying with Huntington’s? Each family member must reach deep inside, reexamine their values and the relationships that matter most as they learn to lead lives not defined by fear, but instead, by love.

Praised for writing that “explores the resilience of the human spirit” (The San Francisco Chronicle), Lisa Genova has once again established her talent with Inside the O’Briens, a novel as powerful and unforgettable as the human insights at its core.


  • Sonja Flynn

    Fantastic!! Couldn't put it down. I recommended this book to all my friends

    1 of 1 people found this review helpful.

  • Claire W.

    Loved it. this book provoked so many emotions in me. I had tears in my eyes, a knot in my throat and butterflies in my tummy. Beautifully written, insightful, really excellent. highly recommended.

  • Cathy B

    Outstanding book about a difficult subject. I had never heard of HD before reading this book. Well narrated and put together

  • Judy Bartlett

    Having a friend with this horrible disease I was interested to find a book about Huntingtons. It is well explained and shows realisticly how members of the family handle the diagnosis and dreaded future. I am hoping this book will bring a new awareness of HD to more of the world and new medications that could lead to a cure.

  • Nancy Krehlik

    Lisa Genova has done it again! She has taken a terrible degenerative disease, explained it well, painted a realistic picture of it, and put it in the middle of a normal, like able family with all of it's everyday challenges, personalities, and foibles. You see the family members grapple with what this diagnosis means to the family as a whole and to each individual. A good read. It is not a "sad" book even though it is a sad situation.

  • Kathleen Matthews

    Difficult to write a review concerning such a sad tale. Huntington Disease is well explained and just plain awful. Enjoyed the family history and the family fun.

Inside the O'Briens: A Novel

by Lisa Genova

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Inside the O'Briens: A Novel, Lisa Genova