A hurricane is brewing in the jungles of the Maya, and the ancient Death Lords are on the warpath. Across the world in Venice, hanging out with his friend Nasty (Anastasia) Smith-Jones, Max Murphy thinks he is safe from their clutches. But when a rogue octopus pulls him off his gondola and tries to drag him down to the underworld, Max realizes that the Death Lords have not finished with him yet.

Soon Max is back in Central America and reunited with the only ones who can help him in his battle—Lola and the howler monkeys Lord 6-Dog and Lady Coco. Once again it’s up to the four of them to save the world. With the hurricane about to hit land, Max and Lola embark on a one-way journey to danger down the blighted Monkey River. Torn between rescuing themselves and rescuing one of the last wild jaguars of the Monkey River region, Max and Lola find themselves drawn into an ever more bizarre series of tests, culminating in a terrifying ballgame that they can never win.