An investigation into a simple cellular-phone fraud leads both Peter Parker and his alter-ego, the Amazing Spider-Man, to a fiendish plot: using unique counterfeiting equipment and a devastatingly large stock-pile of bombs, someone plans to destabilize the world's economy and destroy several major cities. The mysterious corporation CCRC is involved in this plan—and they have caused trouble in the past for Spider-Man and for the alien symbiote Venom, who has sworn to kill Spidey. Soon both hero and villain learn that the mastermind behind that old trouble and the new danger is none other than Spider-Man's oldest, most dangerous enemy: Doctor Octopus. Now Spider-Man and Venom must put aside their differences and join forces to stop the greater menace of Doctor Octopus before the villain devastates the planet!