Jesse McDermitt is starting a new chapter in his life. As captain of the research vessel Ambrosia, his mission is to study the oceans and seafloor, searching for rich oil deposits. His unstated mission is to locate and eradicate the enemies of society on behalf of Armstrong Research, a secretive organization funded by some of the richest men in the world.

When word gets out about a massive drug and human trafficking cartel moving tons of illegal drugs, along with hundreds of slave laborers, out of Venezuela, Jesse is tasked with stopping them at all cost. But how can one man find the traffickers amid the thousands of ships coming and going from Venezuela's ports every year? Can Jesse close on and engage the traffickers?